Silicocarnotite: Novel Silicate Bioceramic With Osteogenic Property for Repairing Rat Cranial Critical-Sized Bone Defects

Critical-sized bone defects are an intractable orthopedic disease which often fails to regenerate spontaneously and requires additional intervention. Current therapies, including autografts allografts, not always satisfactory. Herein, the novel calcium phosphate bioceramic-containing silicon (CPS) with a carnotite structure was synthesized. In present study, CPS prepared for investigating biocompatibility bioactivity in vitro vivo comparison hydroxyapatite (HA). Our results showed that bioceramics had favorable rBMSCs could adhere on surface well . Moreover, promote osteogenic differentiation of expression marker genes, ALP, Runx-2, BSP, OCN, OPN. , micro-CT, histomorphometry, histology analyses significantly enhanced critical-sized calvarial healing compared HA. Overall, study demonstrated satisfactory bioactivities capacities, be potential option reconstructing defects.